Preterm labor: one syndrome, many causes

R Romero, SK Dey, SJ Fisher - Science, 2014 - science.org
R Romero, SK Dey, SJ Fisher
Science, 2014science.org
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant
morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple
pathologic processes, leads to 70% of preterm births. The prevention and the treatment of
preterm labor have been long-standing challenges. We summarize the current
understanding of the mechanisms of disease implicated in this condition and review
advances relevant to intra-amniotic infection, decidual senescence, and breakdown of …
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.
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