MN1, a novel player in human AML
GC Grosveld - Blood Cells, Molecules, and Diseases, 2007 - Elsevier
The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain
types of human acute myeloid leukemia. Upregulation is invariantly associated with inv (16)
AML but is also found in other AML subtypes. Overexpression of this gene is also associated
with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In
this short review, I will discuss the role of MN1 in myeloid leukemia.
types of human acute myeloid leukemia. Upregulation is invariantly associated with inv (16)
AML but is also found in other AML subtypes. Overexpression of this gene is also associated
with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In
this short review, I will discuss the role of MN1 in myeloid leukemia.