Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C …
U Beuers, M Bilzer, A Chittattu, GA Kullak-Ublick… - Hepatology, 2001 - Elsevier
Ursodeoxycholic acid (UDCA) exerts anticholestatic effects by undefined mechanisms.
Previous work suggested that UDCA stimulates biliary exocytosis via Ca++-and protein
kinase C (PKC)-dependent mechanisms. Therefore, the effect of taurine-conjugated UDCA
(TUDCA) was studied in the experimental model of taurolithocholic acid (TLCA)-induced
cholestasis on bile flow, hepatobiliary exocytosis, distribution of PKC isoforms, and density
of the apical conjugate export pump, Mrp2, in canalicular membranes. Isolated perfused rat …
Previous work suggested that UDCA stimulates biliary exocytosis via Ca++-and protein
kinase C (PKC)-dependent mechanisms. Therefore, the effect of taurine-conjugated UDCA
(TUDCA) was studied in the experimental model of taurolithocholic acid (TLCA)-induced
cholestasis on bile flow, hepatobiliary exocytosis, distribution of PKC isoforms, and density
of the apical conjugate export pump, Mrp2, in canalicular membranes. Isolated perfused rat …