Mitochondrial and fatty changes in hepatocytes of patients with Wilson's disease
I Sternlieb - Gastroenterology, 1968 - Elsevier
I Sternlieb
Gastroenterology, 1968•ElsevierThe liver plays at least two roles in the pathogenesis of Wilson's disease. First, its inability to
synthesize normal amounts of ceruloplasmin appears to be closely related to the
accumulation of excessive amounts of hepatic copper. Second, the liver is a target at which
the toxic effects of these copper deposits are directed and where they ultimately produce
postnecrotic cirrhosis. 1• 2
synthesize normal amounts of ceruloplasmin appears to be closely related to the
accumulation of excessive amounts of hepatic copper. Second, the liver is a target at which
the toxic effects of these copper deposits are directed and where they ultimately produce
postnecrotic cirrhosis. 1• 2
The liver plays at least two roles in the pathogenesis of Wilson's disease. First, its inability to synthesize normal amounts of ceruloplasmin appears to be closely related to the accumulation of excessive amounts of hepatic copper. Second, the liver is a target at which the toxic effects of these copper deposits are directed and where they ultimately produce postnecrotic cirrhosis. 1• 2
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