[HTML][HTML] Stimulation of NFκB activity by multiple signaling pathways requires PAK1

JA Frost, JL Swantek, S Stippec, MJ Yin… - Journal of Biological …, 2000 - ASBMB
The p21-activated kinase (PAK1) is a serine-threonine protein kinase that is activated by
binding to the Rho family small G proteins Rac and Cdc42hs. Both Rac and Cdc42hs have
been shown to regulate the activity of the transcription factor NFκB. Here we show that
expression of active Ras, Raf-1, or Rac1 in fibroblasts stimulates NFκB in a PAK1-
dependent manner and that expression of active PAK1 can stimulate NFκB on its own.
Similarly, in macrophages activation of NFκB as well as transcription from the tumor necrosis …