Psoriasis is associated with increased β-defensin genomic copy number
EJ Hollox, U Huffmeier, PLJM Zeeuwen, R Palla… - Nature …, 2008 - nature.com
EJ Hollox, U Huffmeier, PLJM Zeeuwen, R Palla, J Lascorz, D Rodijk-Olthuis…
Nature genetics, 2008•nature.comPsoriasis is a common inflammatory skin disease with a strong genetic component. We
analyzed the genomic copy number polymorphism of the β-defensin region on human
chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German
individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a
significant association between higher genomic copy number for β-defensin genes and risk
of psoriasis.
analyzed the genomic copy number polymorphism of the β-defensin region on human
chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German
individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a
significant association between higher genomic copy number for β-defensin genes and risk
of psoriasis.
Abstract
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
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