[HTML][HTML] Structure of the extracellular domain of Tie receptor tyrosine kinases and localization of the angiopoietin-binding epitope
PR Macdonald, P Progias, B Ciani, S Patel… - Journal of biological …, 2006 - ASBMB
Angiogenesis is essential for tissue repair and regeneration during wound healing but also
plays important roles in many pathological processes including tumor growth and
metastasis. The receptor protein tyrosine kinase Tie2 and its ligands, the angiopoietins,
have important functions in the regulation of angiogenesis. Here, we report a detailed
structural and functional characterization of the extracellular region of Tie2. Sequence
analysis of the extracellular domain revealed an additional immunoglobulin-like domain …
plays important roles in many pathological processes including tumor growth and
metastasis. The receptor protein tyrosine kinase Tie2 and its ligands, the angiopoietins,
have important functions in the regulation of angiogenesis. Here, we report a detailed
structural and functional characterization of the extracellular region of Tie2. Sequence
analysis of the extracellular domain revealed an additional immunoglobulin-like domain …