[HTML][HTML] Proteasomal degradation of γ-aminobutyric acidB receptors is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and …
K Zemoura, D Benke - Journal of Biological Chemistry, 2014 - ASBMB
Regulation of cell surface expression of neurotransmitter receptors is crucial for determining
synaptic strength and plasticity, but the underlying mechanisms are not well understood. We
previously showed that proteasomal degradation of GABA B receptors via the endoplasmic
reticulum (ER)-associated protein degradation (ERAD) machinery determines the number of
cell surface GABA B receptors and thereby GABA B receptor-mediated neuronal inhibition.
Here, we show that proteasomal degradation of GABA B receptors requires the interaction of …
synaptic strength and plasticity, but the underlying mechanisms are not well understood. We
previously showed that proteasomal degradation of GABA B receptors via the endoplasmic
reticulum (ER)-associated protein degradation (ERAD) machinery determines the number of
cell surface GABA B receptors and thereby GABA B receptor-mediated neuronal inhibition.
Here, we show that proteasomal degradation of GABA B receptors requires the interaction of …