Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor α3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain …
K Hösl, H Reinold, RJ Harvey, U Müller, S Narumiya… - Pain, 2006 - Elsevier
Inflammation, peripheral nerve injury and chemical irritants can cause central sensitization
in pain pathways. Prostaglandins produced in the CNS induce central sensitization during
inflammation mainly by relieving nociceptive neurons from glycinergic inhibition. We have
recently identified spinal prostaglandin E receptors of the EP2 subtype (EP2 receptors) and
the glycine receptor α3 subunit (GlyRα3) as signal transduction elements involved in the
generation of central inflammatory hyperalgesia. It is however still unknown to what extent …
in pain pathways. Prostaglandins produced in the CNS induce central sensitization during
inflammation mainly by relieving nociceptive neurons from glycinergic inhibition. We have
recently identified spinal prostaglandin E receptors of the EP2 subtype (EP2 receptors) and
the glycine receptor α3 subunit (GlyRα3) as signal transduction elements involved in the
generation of central inflammatory hyperalgesia. It is however still unknown to what extent …