[HTML][HTML] High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation
KJ Leuchowius, M Jarvius, M Wickström… - Molecular & Cellular …, 2010 - ASBMB
The cost of developing new drugs is a major obstacle for pharmaceutical companies and
academia with many drugs identified in the drug discovery process failing approval for
clinical use due to lack of intended effect or because of severe side effects. Since the early
1990s, high throughput screening of drug compounds has increased enormously in capacity
but has not resulted in a higher success rate of the identified drugs. Thus, there is a need for
methods that can identify biologically relevant compounds and more accurately predict in …
academia with many drugs identified in the drug discovery process failing approval for
clinical use due to lack of intended effect or because of severe side effects. Since the early
1990s, high throughput screening of drug compounds has increased enormously in capacity
but has not resulted in a higher success rate of the identified drugs. Thus, there is a need for
methods that can identify biologically relevant compounds and more accurately predict in …