[HTML][HTML] Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels
JE Carland, MA Cooper, S Sugiharto, HJ Jeong… - Journal of biological …, 2009 - ASBMB
The Cys loop receptor channels mediate fast synaptic transmission in the nervous system.
The M2-demarcated transmembrane pore is an important determinant of their ion
permeation properties. Portals within the intracellular domain are also part of the permeation
pathway in cationic Cys loop receptors, with charged residues in a helical MA stretch
partially lining these openings profoundly affecting channel conductance. It is unknown
whether analogous portals contribute to the permeation pathway in anionic Cys loop …
The M2-demarcated transmembrane pore is an important determinant of their ion
permeation properties. Portals within the intracellular domain are also part of the permeation
pathway in cationic Cys loop receptors, with charged residues in a helical MA stretch
partially lining these openings profoundly affecting channel conductance. It is unknown
whether analogous portals contribute to the permeation pathway in anionic Cys loop …