Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia
C Yallampalli, RE Garfield - American journal of obstetrics and gynecology, 1993 - Elsevier
Objectives: Preeclampsia is associated with hypertension, fetal growth retardation, and
proteinurea. We hypothesized that impaired vascular nitric oxide synthesis during
pregnancy may be an important causal factor in preeclampsia. Study Design: An inhibitor of
nitric oxide synthase, L-nitro-arginine methyl ester, or a nitric oxide donor, nitroglycerin, was
infused subcutaneously to rats at a constant rate from day 17 of gestation. Systolic blood
pressure, day of spontaneous delivery, weight, and mortality rate of pups were recorded …
proteinurea. We hypothesized that impaired vascular nitric oxide synthesis during
pregnancy may be an important causal factor in preeclampsia. Study Design: An inhibitor of
nitric oxide synthase, L-nitro-arginine methyl ester, or a nitric oxide donor, nitroglycerin, was
infused subcutaneously to rats at a constant rate from day 17 of gestation. Systolic blood
pressure, day of spontaneous delivery, weight, and mortality rate of pups were recorded …