eNOS deficiency acts through endothelin to aggravate sFlt-1–induced pre-eclampsia–like phenotype

F Li, JR Hagaman, HS Kim, N Maeda… - Journal of the …, 2012 - journals.lww.com
Excess soluble fms-like tyrosine kinase 1 (sFlt-1) of vascular endothelial growth factor
receptor 1 secreted from the placenta causes pre-eclampsia–like features by antagonizing
vascular endothelial growth factor signaling, which can lead to reduced endothelial nitric
oxide synthase (eNOS) activity; the effect of this concomitant decrease in eNOS activity is
unknown. We tested whether the decrease in nitric oxide occurring in female mice lacking
eNOS aggravates the pre-eclampsia–like phenotype induced by increased sFlt-1. Untreated …