Nitric oxide (NO) is one of the most pleiotropic signaling molecules at systemic and cellular
levels, participating in vascular tone regulation, cellular respiration, proliferation, apoptosis
and gene expression. Indeed NO actively participates in trophoblast invasion, placental
development and represents the main vasodilator in this tissue. Despite the large number of
studies addressing the role of NO in the placenta, its participation in placental vascular
development and the effect of altered levels of NO on placental function remains to be …