The role of nitric oxide in the pathogenesis of preeclampsia
SP Seligman, JP Buyon, RM Clancy, BK Young… - American journal of …, 1994 - Elsevier
Objective: Nitric oxide, a potent vasodilator released by endothelial cells, inhibits platelet
aggregation and adhesion to vascular endothelial surfaces. Because endothelial cell
damage is considered pivotal in the pathogenesis of preeclampsia, this study was initiated
to determine whether nitric oxide production is decreased in patients with preeclampsia.
Study Design: Twenty-six patients with preeclampsia (as defined by a blood pressure≥ 140
mm Hg systolic or 90 mm Hg diastolic plus proteinuria,≥ 300 mg per 24 hours or≥ 2+ by …
aggregation and adhesion to vascular endothelial surfaces. Because endothelial cell
damage is considered pivotal in the pathogenesis of preeclampsia, this study was initiated
to determine whether nitric oxide production is decreased in patients with preeclampsia.
Study Design: Twenty-six patients with preeclampsia (as defined by a blood pressure≥ 140
mm Hg systolic or 90 mm Hg diastolic plus proteinuria,≥ 300 mg per 24 hours or≥ 2+ by …