Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis …
KL Rice, DJ Izon, J Ford, A Boodhoo, UR Kees… - Leukemia research, 2008 - Elsevier
TLX1/HOX11 is an oncogenic transcription factor in human T-cell leukemia, however, the
molecular basis for its transforming activity has remained elusive. The ALDH1A1 gene,
whose product participates in retinoic acid synthesis, was previously identified as a TLX1-
responsive gene. Here, we confirm regulation of ALDH1A1 transcription by TLX1 and show
that ALDH1A1 can profoundly perturb murine hematopoiesis by promoting myeloid
differentiation at the expense of lymphopoiesis. Together, these data demonstrate that …
molecular basis for its transforming activity has remained elusive. The ALDH1A1 gene,
whose product participates in retinoic acid synthesis, was previously identified as a TLX1-
responsive gene. Here, we confirm regulation of ALDH1A1 transcription by TLX1 and show
that ALDH1A1 can profoundly perturb murine hematopoiesis by promoting myeloid
differentiation at the expense of lymphopoiesis. Together, these data demonstrate that …