Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus
GC Zeller, J Hirahashi, A Schwarting… - Journal of the …, 2006 - journals.lww.com
Abstract MRL/MpJ-Tnfrsf6 lpr (MRL-Fas lpr) mice develop a spontaneous T cell–dependent
autoimmune disease that shares features with human lupus, including fatal nephritis,
systemic pathology, and autoantibodies (autoAb). The inducible co-stimulator (ICOS) is
upregulated on activated T cells and modulates T cell–mediated responses. To investigate
whether ICOS has an essential role in regulating autoimmune lupus nephritis and the
systemic illness in MRL-Fas lpr mice, ICOS null (−/−) MRL Fas lpr and ICOS intact (+/+) MRL …
autoimmune disease that shares features with human lupus, including fatal nephritis,
systemic pathology, and autoantibodies (autoAb). The inducible co-stimulator (ICOS) is
upregulated on activated T cells and modulates T cell–mediated responses. To investigate
whether ICOS has an essential role in regulating autoimmune lupus nephritis and the
systemic illness in MRL-Fas lpr mice, ICOS null (−/−) MRL Fas lpr and ICOS intact (+/+) MRL …