[HTML][HTML] The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase …
K Sunahori, K Nagpal, CM Hedrich, M Mizui… - Journal of Biological …, 2013 - ASBMB
DNA hypomethylation is a characteristic feature of systemic lupus erythematosus (SLE)
immune cells. Numerous reports have implicated the involvement of the MEK/ERK pathway
in the reduction of DNA methyltransferase (DNMT) expression, hence inducing the
transcription of methylation-sensitive genes in SLE patients. However, the molecular
mechanisms involved remain unclear. Here, we investigated whether the catalytic subunit of
protein phosphatase 2A (PP2Ac), which is overexpressed in SLE T-cells, contributes to …
immune cells. Numerous reports have implicated the involvement of the MEK/ERK pathway
in the reduction of DNA methyltransferase (DNMT) expression, hence inducing the
transcription of methylation-sensitive genes in SLE patients. However, the molecular
mechanisms involved remain unclear. Here, we investigated whether the catalytic subunit of
protein phosphatase 2A (PP2Ac), which is overexpressed in SLE T-cells, contributes to …