Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation

G Casorati, C de Lalla, P Dellabona - Oncoimmunology, 2012 - Taylor & Francis
Oncoimmunology, 2012Taylor & Francis
CD1d-restricted invariant (i) NKT cells are innate-like, lipid-reactive T lymphocytes
implicated in the control of infections, cancer and autoimmunity. Our study suggests that the
reconstitution of the peripheral iNKT cell compartment, following HLA-haploidentical
hematopoietic stem cell transplantation, associates with leukemia control in children affected
by different hematological malignancies.
CD1d-restricted invariant (i)NKT cells are innate-like, lipid-reactive T lymphocytes implicated in the control of infections, cancer and autoimmunity. Our study suggests that the reconstitution of the peripheral iNKT cell compartment, following HLA-haploidentical hematopoietic stem cell transplantation, associates with leukemia control in children affected by different hematological malignancies.
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