Vα24+ NKT cells are decreased in elderly humans
O DelaRosa, R Tarazona, JG Casado, C Alonso… - Experimental …, 2002 - Elsevier
Natural killer T (NKT) cells represent a novel cell lineage characterized by the restricted
expression of an invariant TCRα chain encoded by Vα24/JαQ gene segments in humans
and Vα14/Jα281+ in mice. Different aspects of the immune response are severely affected
by age. Thus, we have studied the effect of aging on NKT cells from healthy elderly
individuals. Our results demonstrated a decreased percentage of CD3+ Vα24+ cells in
peripheral blood from elderly donors, whereas mainstream T lymphocytes showed an age …
expression of an invariant TCRα chain encoded by Vα24/JαQ gene segments in humans
and Vα14/Jα281+ in mice. Different aspects of the immune response are severely affected
by age. Thus, we have studied the effect of aging on NKT cells from healthy elderly
individuals. Our results demonstrated a decreased percentage of CD3+ Vα24+ cells in
peripheral blood from elderly donors, whereas mainstream T lymphocytes showed an age …