Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family
H Bolz, A Ramı́rez, B von Brederlow… - Biochimica et Biophysica …, 2001 - Elsevier
ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type 1
modules) proteins constitute a family of zinc metalloproteinases which target and process
extracellular matrix proteins. We cloned and characterized a novel human ADAMTS gene,
ADAMTS14, which is located on human chromosome 10q2. ADAMTS14 exhibits the
characteristic multidomain structure of ADAMTS proteins including four thrombospondin
modules and shows highest similarity to ADAMTS3 and ADAMTS2. By RT-PCR analysis we …
modules) proteins constitute a family of zinc metalloproteinases which target and process
extracellular matrix proteins. We cloned and characterized a novel human ADAMTS gene,
ADAMTS14, which is located on human chromosome 10q2. ADAMTS14 exhibits the
characteristic multidomain structure of ADAMTS proteins including four thrombospondin
modules and shows highest similarity to ADAMTS3 and ADAMTS2. By RT-PCR analysis we …