Context Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at
high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial
pressure may depend on iron status, possibly acting through the transcription factor hypoxia-
inducible factor, but the pathophysiological and clinical importance of this interaction is
unknown. Objective To determine whether increasing or decreasing iron availability
modifies altitude-induced hypoxic pulmonary hypertension. Design, Setting, and Participants …