Accurate measurement of intestinal transit in the rat
MS Miller, JJ Galligan, TF Burks - Journal of pharmacological methods, 1981 - Elsevier
A new method for quantifying intestinal transit was evaluated by comparison with two other
popular techniques. The distribution of radiochromium (51 Cr) throughout the small intestine
of rats previously treated with saline (1.0 ml/kg sc), capsaicin (10 mg. kg sc), hexamethonium
(20 mg/kg ip), D-ala 2-met-enkephalinamide (1.0 μg icv), or neostigmine (0.1 mg/kg ip) was
quantified by (1) measuring the most distal intestinal segment reached by chromium,(2)
calculating the slope produced by linear regression analysis on cumulative percent …
popular techniques. The distribution of radiochromium (51 Cr) throughout the small intestine
of rats previously treated with saline (1.0 ml/kg sc), capsaicin (10 mg. kg sc), hexamethonium
(20 mg/kg ip), D-ala 2-met-enkephalinamide (1.0 μg icv), or neostigmine (0.1 mg/kg ip) was
quantified by (1) measuring the most distal intestinal segment reached by chromium,(2)
calculating the slope produced by linear regression analysis on cumulative percent …