The absence of tryptophan hydroxylase activity in blood platelets

JJ Morrissey, MN Walker… - Proceedings of the …, 1977 - journals.sagepub.com
JJ Morrissey, MN Walker, W Lovenberg
Proceedings of the Society for Experimental Biology and Medicine, 1977journals.sagepub.com
Under conditions that support maximal tryptophan hydroxylating activity in extracts from
pineal glands and brain no hydroxylase activity could be detected in platelets. Furthermore,
with systems that are adequate to measure serotonin synthesis in cultured pineal glands or
whole cells, no serotonin synthetic capacity could be detected in human or rat blood
platelets.
Summary
Under conditions that support maximal tryptophan hydroxylating activity in extracts from pineal glands and brain no hydroxylase activity could be detected in platelets. Furthermore, with systems that are adequate to measure serotonin synthesis in cultured pineal glands or whole cells, no serotonin synthetic capacity could be detected in human or rat blood platelets.
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