Biologic and prognostic significance of hepatocyte hepatitis B core antigen expressions in the natural course of chronic hepatitis B virus infection
HC Hsu, IJ Su, MY Lai, DS Chen, MH Chang… - Journal of …, 1987 - Elsevier
To elucidate the biologic significance of hepatocyte hepatitis B core antigen (HBcAg)
expression and its relation to the natural course of hepatitis B virus (HBV) infection, the
patterns of HBcAg were correlated with HBV virus replication state and the disease activity in
598 needle liver biopsies performed on 569 hepatitis B surface antigen (HBsAg) carriers
aged 1–81 years. A good correlation of liver HBcAg with serum HBeAg and HBV DNA status
was demonstrated. HBcAg was present in the hepatocyte nuclei (nHBcAg) or cytoplasm …
expression and its relation to the natural course of hepatitis B virus (HBV) infection, the
patterns of HBcAg were correlated with HBV virus replication state and the disease activity in
598 needle liver biopsies performed on 569 hepatitis B surface antigen (HBsAg) carriers
aged 1–81 years. A good correlation of liver HBcAg with serum HBeAg and HBV DNA status
was demonstrated. HBcAg was present in the hepatocyte nuclei (nHBcAg) or cytoplasm …