Persistence of hepatitis B virus DNA in serum and liver from patients with chronic hepatitis B after loss of HBsAg
MA Loriot, P Marcellin, F Walker, N Boyer, C Degott… - Journal of …, 1997 - Elsevier
Background/Aims: The persistence of serum and liver hepatitis B virus (HBV) sequences in
patients with chronic hepatitis B after loss of HBsAg has already been described. We have
attempted to elucidate the significance of these HBV sequences after loss of HBsAg.
Methods: Fifteen patients were studied. We looked for serum and liver HBV DNA, using
polymerase chain reaction (PCR) with different sets of primers and in situ hybridization. The
sedimentation velocity of serum HBV DNA was measured on a gradient of sucrose in two …
patients with chronic hepatitis B after loss of HBsAg has already been described. We have
attempted to elucidate the significance of these HBV sequences after loss of HBsAg.
Methods: Fifteen patients were studied. We looked for serum and liver HBV DNA, using
polymerase chain reaction (PCR) with different sets of primers and in situ hybridization. The
sedimentation velocity of serum HBV DNA was measured on a gradient of sucrose in two …