Correlation between liver histology and markers of hepatitis B virus replication in infected patients: a study by in situ hybridization
CJ Burrell, EJ Gowans, R Rowland, P Hall… - Hepatology, 1984 - journals.lww.com
Liver sections from 18 patients positive for hepatitis B surface antigen (HBsAg), and from 12
negative patients, were examined for the presence of hepatitis B virus (HBV) DNA using an
in situ hybridization assay that would identify only those hepatocytes containing more than
10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral
replication, rather than latent infection. The findings were correlated with results of tissue
immunofluorescence for HBV antigens and the presence of serum hepatitis B e antigen …
negative patients, were examined for the presence of hepatitis B virus (HBV) DNA using an
in situ hybridization assay that would identify only those hepatocytes containing more than
10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral
replication, rather than latent infection. The findings were correlated with results of tissue
immunofluorescence for HBV antigens and the presence of serum hepatitis B e antigen …