[HTML][HTML] TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP
TRPM8 is the molecular sensor for cold; however, the physiological role of TRPM8+ neurons
at mucosal surfaces is unclear. Here we evaluated the distribution and peptidergic
properties of TRPM8+ fibers in naive and inflamed colons, as well as their role in mucosal
inflammation. We found that Trpm8−/− mice were hypersusceptible to dextran sodium sulfate
(DSS)-induced colitis, and that Trpm8−/− CD11c+ DCs (dendritic cells) showed
hyperinflammatory responses to toll-like receptor (TLR) stimulation. This was phenocopied …
at mucosal surfaces is unclear. Here we evaluated the distribution and peptidergic
properties of TRPM8+ fibers in naive and inflamed colons, as well as their role in mucosal
inflammation. We found that Trpm8−/− mice were hypersusceptible to dextran sodium sulfate
(DSS)-induced colitis, and that Trpm8−/− CD11c+ DCs (dendritic cells) showed
hyperinflammatory responses to toll-like receptor (TLR) stimulation. This was phenocopied …