[HTML][HTML] Lipoapoptosis in beta-cells of obese prediabeticfa/fa rats: role of serine palmitoyltransferase overexpression
M Shimabukuro, M Higa, YT Zhou, MY Wang… - Journal of Biological …, 1998 - ASBMB
We reported that the lipoapoptosis of beta-cells observed in fat-laden islets of obese fa/fa
Zucker Diabetic Fatty (ZDF) rats results from overproduction of ceramide, an initiator of the
apoptotic cascade and is induced by long-chain fatty acids (FA). Whereas the ceramide of
cytokine-induced apoptosis may be derived from sphingomyelin hydrolysis, FA-induced
ceramide overproduction seems to be derived from FA. We therefore semiquantified mRNA
of serine palmitoyltransferase (SPT), which catalyzes the first step in ceramide synthesis. It …
Zucker Diabetic Fatty (ZDF) rats results from overproduction of ceramide, an initiator of the
apoptotic cascade and is induced by long-chain fatty acids (FA). Whereas the ceramide of
cytokine-induced apoptosis may be derived from sphingomyelin hydrolysis, FA-induced
ceramide overproduction seems to be derived from FA. We therefore semiquantified mRNA
of serine palmitoyltransferase (SPT), which catalyzes the first step in ceramide synthesis. It …