[HTML][HTML] Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

CL Kelpe, PC Moore, SD Parazzoli, B Wicksteed… - Journal of Biological …, 2003 - ASBMB
Chronic exposure to elevated levels of fatty acids impairs pancreatic beta cell function, a
phenomenon thought to contribute to the progressive deterioration of insulin secretion in
type 2 diabetes. We have previously demonstrated that prolonged exposure of isolated islets
to elevated levels of palmitate inhibits preproinsulin mRNA levels in the presence of high
glucose concentrations. However, whether this occurs via transcriptional or post-
transcriptional mechanisms has not been determined. In addition, the nature of the lipid …