[HTML][HTML] The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

MM Gottesman, V Ling - FEBS letters, 2006 - Elsevier
MM Gottesman, V Ling
FEBS letters, 2006Elsevier
The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux
pump, as a mechanism of multidrug resistance in cancer is generally accepted as a
significant contribution to the ongoing effort to end death and suffering from this disease. The
historical reflections of Victor Ling and Michael Gottesman concerning the early years of this
research highlight the important contributions of the multidisciplinary teams involved in these
studies, and illustrate how technological developments in biochemistry and molecular and …
The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery.
Elsevier