[HTML][HTML] The β3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
KJ Soeder, SK Snedden, W Cao… - Journal of Biological …, 1999 - ASBMB
Promiscuous coupling between G protein-coupled receptors and multiple species of
heterotrimeric G proteins provides a potential mechanism for expanding the diversity of G
protein-coupled receptor signaling. We have examined the mechanism and functional
consequences of dual G s/G i protein coupling of the β 3-adrenergic receptor (β 3 AR) in 3T3-
F442A adipocytes. The β 3 AR selective agonist disodium (R, R)-5-[2 [[2-(3-chlorophenyl)-2-
hydroxyethyl]-amino] propyl]-1, 3-benzodioxole-2, 2-dicarboxylate (CL316, 243) stimulated a …
heterotrimeric G proteins provides a potential mechanism for expanding the diversity of G
protein-coupled receptor signaling. We have examined the mechanism and functional
consequences of dual G s/G i protein coupling of the β 3-adrenergic receptor (β 3 AR) in 3T3-
F442A adipocytes. The β 3 AR selective agonist disodium (R, R)-5-[2 [[2-(3-chlorophenyl)-2-
hydroxyethyl]-amino] propyl]-1, 3-benzodioxole-2, 2-dicarboxylate (CL316, 243) stimulated a …
