Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism
S Fang, X Wu, Z Han, X Zhang, C Wang… - Chinese medical …, 2010 - journals.lww.com
Background Neuregulin-1 (NRG-1), the ligand of the myocardial ErbB receptor, is a protein
mediator with regulatory actions in the heart. This study investigated whether NRG-1
preconditioning has protective effects on myocardial ischemia/reperfusion (I/R) injury and its
potential mechanism. Methods We worked with an in vivo rat model with induced myocardial
ischemia (45 minutes) followed by reperfusion (3 hours). NRG-1 message was detected in
the heart using RT-PCR and the protein levels of NRG-1 and ErbB4 were detected by …
mediator with regulatory actions in the heart. This study investigated whether NRG-1
preconditioning has protective effects on myocardial ischemia/reperfusion (I/R) injury and its
potential mechanism. Methods We worked with an in vivo rat model with induced myocardial
ischemia (45 minutes) followed by reperfusion (3 hours). NRG-1 message was detected in
the heart using RT-PCR and the protein levels of NRG-1 and ErbB4 were detected by …