Mechanisms of angiogenesis

W Risau - Nature, 1997 - nature.com
W Risau
Nature, 1997nature.com
After the developing embryo has formed a primary vascular plexus by a process termed
vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting
angiogenesis, which are progressively pruned and remodelled into a functional adult
circulatory system. Recent results, particularly from the study of mice lacking some of the
signalling systems involved, have greatly improved our understanding of the molecular
basis underlying these events, and may suggest new approaches for treating conditions …
Abstract
After the developing embryo has formed a primary vascular plexus by a process termed vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting angiogenesis, which are progressively pruned and remodelled into a functional adult circulatory system. Recent results, particularly from the study of mice lacking some of the signalling systems involved, have greatly improved our understanding of the molecular basis underlying these events, and may suggest new approaches for treating conditions such as cancer that depend on angiogenesis.
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