[HTML][HTML] MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke

XS Liu, M Chopp, XL Wang, L Zhang… - Journal of Biological …, 2013 - ASBMB
The role of microRNAs (miRNAs) in mediating adult neurogenesis after stroke has not been
extensively studied. The present study investigated the function of the miR17-92 cluster in
adult neural progenitor cells after experimental stroke. We found that stroke substantially up-
regulated miR17-92 cluster expression in neural progenitor cells of the adult mouse.
Overexpression of the miR17-92 cluster either in cultured ischemic neural progenitor cells or
in the subventricular zone (SVZ) of ischemic animals significantly increased cell …