Effects of microglia on neurogenesis

K Sato - Glia, 2015 - Wiley Online Library
K Sato
Glia, 2015Wiley Online Library
This review summarizes and organizes the literature concerning the effects of microglia on
neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and
subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is
progressively restricted during the life of the organism. A comparison of microglial roles in
neurogenesis in these two regions indicates that microglia regulate neurogenesis in a
temporally and spatially specific manner. Microglia may also sense signals from the …
This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394–1405
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