[HTML][HTML] Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice
It has been hypothesized that aquaporin-9 (AQP9) is part of the unknown route of
hepatocyte glycerol uptake. In a previous study, leptin receptor-deficient wild-type mice
became diabetic and suffered from fasting hyperglycemia whereas isogenic AQP9−/− knock-
out mice remained normoglycemic. The reason for this improvement in AQP9−/− mice was
not established before. Here, we show increased glucose output (by 123%±36% SE) in
primary hepatocyte culture when 0.5 mm extracellular glycerol was added. This increase …
hepatocyte glycerol uptake. In a previous study, leptin receptor-deficient wild-type mice
became diabetic and suffered from fasting hyperglycemia whereas isogenic AQP9−/− knock-
out mice remained normoglycemic. The reason for this improvement in AQP9−/− mice was
not established before. Here, we show increased glucose output (by 123%±36% SE) in
primary hepatocyte culture when 0.5 mm extracellular glycerol was added. This increase …