Circulating serum exosomal miRNAs as potential biomarkers for esophageal adenocarcinoma

K Chiam, T Wang, DI Watson, GC Mayne… - Journal of …, 2015 - Elsevier
Background The poor prognosis and rising incidence of esophageal adenocarcinoma
highlight the need for improved detection methods. The potential for circulating microRNAs
(miRNAs) as biomarkers in other cancers has been shown, but circulating miRNAs have not
been well characterized in esophageal adenocarcinoma. We investigated whether
circulating exosomal miRNAs have potential to discriminate individuals with esophageal
adenocarcinoma from healthy controls and non-dysplastic Barrett's esophagus. Methods …