[HTML][HTML] Micromanaging iron homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins

Y Yoshioka, N Kosaka, T Ochiya, T Kato - Journal of Biological Chemistry, 2012 - ASBMB
Iron is fundamental for sustaining life for living organisms, and the iron metabolism is finely
regulated at different levels. In cancer cells, deregulation of the iron metabolism induces
oxidative stress and drives tumor progression and metastasis; however, the molecular
mechanisms of iron homeostasis are not fully understood. Here we found that iron deficiency
as well as hypoxia promoted microRNA-210 (miR-210) expression. A central mediator of
miR-210 transcriptional activation is the hypoxia-inducible factor (HIF)-1α, and the hypoxia …