The prion-like Doppel protein (Dpl) has many biochemical and structural properties in
common with the cellular prion protein (PrP c), and the physiological role of neither protein is
known. Experimental data suggest either direct or indirect interaction between the two
proteins. In this study, we investigated the expression pattern and biochemical
characteristics of Dpl in human tissues and in Chinese hamster ovary cells transfected with
wild-type or variant human Dpl gene constructs. Human Dpl appears to be a …