Repair of large bone defects with the use of autologous bone marrow stromal cells
R Quarto, M Mastrogiacomo, R Cancedda… - New england journal …, 2001 - Mass Medical Soc
New england journal of medicine, 2001•Mass Medical Soc
To the Editor: The reconstruction of large bone segments is an important clinical problem,
and none of the approaches proposed thus far have proved very effective. In animals, repair
and functional recovery of segmental bone defects have been reported with the use of
marrow-derived osteoprogenitor cells grown on scaffolds of macroporous hydroxyapatite. 1–
3 We report the use of this cell-based tissue-engineering approach to treat three patients
with large bone defects. Patient 1 was a 41-year-old woman with loss of a 4.0-cm segment of …
and none of the approaches proposed thus far have proved very effective. In animals, repair
and functional recovery of segmental bone defects have been reported with the use of
marrow-derived osteoprogenitor cells grown on scaffolds of macroporous hydroxyapatite. 1–
3 We report the use of this cell-based tissue-engineering approach to treat three patients
with large bone defects. Patient 1 was a 41-year-old woman with loss of a 4.0-cm segment of …
To the Editor: The reconstruction of large bone segments is an important clinical problem, and none of the approaches proposed thus far have proved very effective. In animals, repair and functional recovery of segmental bone defects have been reported with the use of marrow-derived osteoprogenitor cells grown on scaffolds of macroporous hydroxyapatite.1–3
We report the use of this cell-based tissue-engineering approach to treat three patients with large bone defects. Patient 1 was a 41-year-old woman with loss of a 4.0-cm segment of the mid-diaphysis of the right tibia as the result of an unsuccessful attempt at bone lengthening. Patient . . .
The New England Journal Of Medicine