[HTML][HTML] Challenges in the management of pleomorphic lobular carcinoma in situ of the breast
YA Masannat, SK Bains, SE Pinder, AD Purushotham - The Breast, 2013 - Elsevier
YA Masannat, SK Bains, SE Pinder, AD Purushotham
The Breast, 2013•ElsevierBACKGROUND: Pleomorphic Lobular Carcinoma in Situ (PLCIS) is a pathological variant of
Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade
ago there are only few papers published about this condition. METHODS: Medline and
Pubmed based literature overview was done with the aim of describing the different
histopathological, radiological and clinical features of this pathological entity to highlight the
different clinicopathological presentations and modalities of treatment described. RESULTS …
Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade
ago there are only few papers published about this condition. METHODS: Medline and
Pubmed based literature overview was done with the aim of describing the different
histopathological, radiological and clinical features of this pathological entity to highlight the
different clinicopathological presentations and modalities of treatment described. RESULTS …
BACKGROUND
Pleomorphic Lobular Carcinoma in Situ (PLCIS) is a pathological variant of Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade ago there are only few papers published about this condition.
METHODS
Medline and Pubmed based literature overview was done with the aim of describing the different histopathological, radiological and clinical features of this pathological entity to highlight the different clinicopathological presentations and modalities of treatment described.
RESULTS
PLCIS has different biological features when compared to LCIS. It is more likely to be associated with invasive disease and the immuno-histochemical profile shows it is less likely to be ER and PR positive with higher positivity of HER2, Ki-67and p53. It has been suggested that PLCIS should be treated more aggressively than LCIS and surgically excised in similar fashion to DCIS.
CONCLUSION
PLCIS is a more aggressive variant of LCIS that needs to be managed differently. Surgical excision with clear margins is advised. Further adjuvant treatments have been described in the literature with little evidence to support their use.
Elsevier