MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells
S Utsugi-Kobukai, H Fujimaki, C Hotta, M Nakazawa… - Immunology letters, 2003 - Elsevier
Exosomes are 50–90 nm vesicles with antigen presenting ability carrying major
histocompatibility complex (MHC) class I, class II, abundant co-stimulatory molecules and
some tetraspan proteins. Although dendritic cells (DCs) are one of the professional antigen
presenting cells capable of presenting exogenous antigens in MHC class I-mediated
antigen specific manner (cross-presentation), the cross-presentation ability by exosomes
from immature or mature DCs are unknown. Here we show that exosomes released from …
histocompatibility complex (MHC) class I, class II, abundant co-stimulatory molecules and
some tetraspan proteins. Although dendritic cells (DCs) are one of the professional antigen
presenting cells capable of presenting exogenous antigens in MHC class I-mediated
antigen specific manner (cross-presentation), the cross-presentation ability by exosomes
from immature or mature DCs are unknown. Here we show that exosomes released from …