Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial
TF Reiss, P Chervinsky, RJ Dockhorn… - Archives of internal …, 1998 - jamanetwork.com
Objectives To determine the clinical effect of oral montelukast sodium, a leukotriene receptor
antagonist, in asthmatic patients aged 15 years or more. Design Randomized, multicenter,
double-blind, placebo-controlled, parallel-group study. A 2-week, single-blind, placebo run-
in period was followed by a 12-week, double-blind treatment period (montelukast sodium,
10 mg, or matching placebo, once daily at bedtime) and a 3-week, double-blind, washout
period. Setting/Patients Fifty clinical centers randomly allocated 681 patients with chronic …
antagonist, in asthmatic patients aged 15 years or more. Design Randomized, multicenter,
double-blind, placebo-controlled, parallel-group study. A 2-week, single-blind, placebo run-
in period was followed by a 12-week, double-blind treatment period (montelukast sodium,
10 mg, or matching placebo, once daily at bedtime) and a 3-week, double-blind, washout
period. Setting/Patients Fifty clinical centers randomly allocated 681 patients with chronic …