[HTML][HTML] Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with …

C Kahlert, SA Melo, A Protopopov, J Tang… - Journal of Biological …, 2014 - ASBMB
Exosomes are small vesicles (50–150 nm) of endocytic origin that are released by many
different cell types. Exosomes in the tumor microenvironment may play a key role in
facilitating cell-cell communication. Exosomes are reported to predominantly contain RNA
and proteins. In this study, we investigated whether exosomes from pancreatic cancer cells
and serum from patients with pancreatic ductal adenocarcinoma contain genomic DNA. Our
results provide evidence that exosomes contain> 10-kb fragments of double-stranded …