Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles
E Wieckowski, TL Whiteside - Immunologic research, 2006 - Springer
E Wieckowski, TL Whiteside
Immunologic research, 2006•SpringerMicrovesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The
molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are
distinct. The former express death ligands and mediate apoptosis of activated T cells. The
latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses.
Serving as intercellular communication networks, tumor-derived MV contribute to tumor
escape, while DC-derived MV drive and regulate immune response.
molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are
distinct. The former express death ligands and mediate apoptosis of activated T cells. The
latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses.
Serving as intercellular communication networks, tumor-derived MV contribute to tumor
escape, while DC-derived MV drive and regulate immune response.
Abstract
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
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