APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy

JB Kopp, GW Nelson, K Sampath… - Journal of the …, 2011 - journals.lww.com
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney
disease in African Americans, but whether APOL1-associated glomerular disease has a
distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271
African American cases, 168 European American cases, and 939 control subjects. In a
recessive model, APOL1 variants conferred seventeenfold higher odds (95% CI 11 to 26) for
focal segmental glomerulosclerosis (FSGS) and twenty-nine-fold higher odds (95% CI 13 to …