Differential homeostatic dynamics of human regulatory T-cell subsets following neonatal thymectomy
AWL Schadenberg, T van den Broek… - Journal of allergy and …, 2014 - jacionline.org
LETTERS TO THE EDITOR 277 proportion of proliferation marker Ki67 1 cells, with a
significant increase following thymectomy (Fig 1, E). Thus, these data suggest that there is a
compensatory, selective expansion of Treg cells, leading to an increased percentage of
Foxp3 1 CD4 1 T cells. Next, we studied the dynamics of 2 distinct Treg cell subpopulations;
gating of the FOXP3 1 fractions is illustrated in Figs E2 and E3 in this article's Online
Repository at www. jacionline. org. The naive subpopulation CD45RO 2 FOXP3low (fraction …
significant increase following thymectomy (Fig 1, E). Thus, these data suggest that there is a
compensatory, selective expansion of Treg cells, leading to an increased percentage of
Foxp3 1 CD4 1 T cells. Next, we studied the dynamics of 2 distinct Treg cell subpopulations;
gating of the FOXP3 1 fractions is illustrated in Figs E2 and E3 in this article's Online
Repository at www. jacionline. org. The naive subpopulation CD45RO 2 FOXP3low (fraction …