Oxidative stress in uremia: nature, mechanisms, and potential consequences

ND Vaziri - Seminars in nephrology, 2004 - Elsevier
Oxidative stress has emerged as a constant feature of chronic renal failure (CRF). The
presence of oxidative stress in CRF is evidenced by an overabundance of lipid,
carbohydrate, and protein oxidation products in the plasma and tissues of uremic patients
and animals. We recently have shown that oxidative stress in CRF animals is associated
with and, in part, owing to up-regulation of superoxide-producing enzyme, nicotinamide-
adenine dinucleotide phosphate (NAD (P) H) oxidase, and down-regulation of superoxide …