The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure

JH Campbell, AC Hearps, GE Martin, KC Williams… - Aids, 2014 - journals.lww.com
JH Campbell, AC Hearps, GE Martin, KC Williams, SM Crowe
Aids, 2014journals.lww.com
Monocytes and macrophages play critical roles in HIV transmission, viral spread early in
infection, and as a reservoir of virus throughout infection. There has been a recent
resurgence of interest in the biology of monocyte subsets and macrophages and their role in
HIV pathogenesis, partly fuelled by efforts to understand difficulties in achieving HIV
eradication. This article examines the importance of monocyte subsets and tissue
macrophages in HIV pathogenesis. Additionally, we will review the role of monocytes and …
Abstract
Monocytes and macrophages play critical roles in HIV transmission, viral spread early in infection, and as a reservoir of virus throughout infection. There has been a recent resurgence of interest in the biology of monocyte subsets and macrophages and their role in HIV pathogenesis, partly fuelled by efforts to understand difficulties in achieving HIV eradication. This article examines the importance of monocyte subsets and tissue macrophages in HIV pathogenesis. Additionally, we will review the role of monocytes and macrophages in the development of serious non-AIDS events including cardiovascular disease and neurocognitive impairment, their significance in viral persistence, and how these cells represent an important obstacle to achieving HIV eradication.
Lippincott Williams & Wilkins